Pathophysiology
Clinical meaning
Alzheimer disease is an irreversible and progressive dementia caused by neurodegenerative changes in the brain from abnormal protein buildup. Beta-amyloid plaques accumulate between neurons and tau protein tangles form inside neurons, resulting in cell damage and neuronal death. These changes develop over time, leading to progressive cognitive decline. The nurse monitors for changes in cognition, behavior, and functional ability, assists with activities of daily living, maintains safety, and reports changes to the nursing team.