Overview
Introduction
Prostaglandins (PGs) are lipid mediators derived from arachidonic acid that play central roles in reproductive physiology.
Prostaglandins (PGs) are lipid mediators derived from arachidonic acid that play central roles in reproductive physiology. In labor induction, two prostaglandin products are used: 1. Dinoprostone (PGE2) — Cervidil (vaginal insert), Prepidil (intracervical gel), Prostin E2 (vaginal suppository for second trimester) 2. Misoprostol (PGE1 analog) — Cytotec; oral or intravaginal use for cervical ripening, induction, and postpartum hemorrhage The cervix undergoes a process called "ripening" in preparation for labor — it softens, effaces, and dilates. In patients with an unripe cervix (high Bishop score needed for favorable outcome), prostaglandins accelerate this process. Bishop Score: A cervical assessment scoring system (0–13); scores <6 indicate an unfavorable cervix likely to benefit from ripening agents.