Pathophysiology
Clinical meaning
HELLP (Hemolysis, Elevated Liver enzymes, Low Platelets) represents severe end of preeclampsia spectrum. Endothelial dysfunction triggers platelet activation and fibrin deposition in hepatic sinusoids. Microangiopathic hemolytic anemia (MAHA) destroys RBCs as they traverse damaged vasculature. Hepatocyte necrosis from ischemia can progress to subcapsular hematoma and hepatic rupture. Connect HELLP Syndrome: Hepatic Cascade to bedside cues you will reassess first: vitals trends, work of breathing, perfusion, mentation, and pain or ischemic equivalents when relevant. Boards reward recognizing when subtle instability outweighs reassurance, then selecting nursing actions that protect airway, circulation, and neurologic status before routine tasks.