Pathophysiology
Clinical meaning
ANCA-associated vasculitis includes GPA (c-ANCA/PR3), MPA (p-ANCA/MPO), and EGPA (eosinophilia + p-ANCA). These small-vessel vasculitides cause necrotizing inflammation with pauci-immune glomerulonephritis. GPA: upper/lower respiratory tract granulomas with renal involvement. MPA: rapidly progressive GN without granulomas. Treatment: induction with cyclophosphamide or rituximab + glucocorticoids, then maintenance with rituximab or azathioprine. Connect Eosinophilic Granulomatosis with Polyangiitis to bedside cues you will reassess first: vitals trends, work of breathing, perfusion, mentation, and pain or ischemic equivalents when relevant. Boards reward recognizing when subtle instability outweighs reassurance, then selecting nursing actions that protect airway, circulation, and neurologic status before routine tasks.