Pathophysiology
Clinical meaning
Acute Hemolytic: ABO incompatibility leads to IgM antibodies attacking donor RBCs, causing complement activation, massive hemolysis, and inflammatory cytokine release (Shock/DIC). Febrile Non-Hemolytic: Cytokines released from donor leukocytes accumulate during storage. Connect Transfusion Reactions: Hemolytic vs Febrile to bedside cues you will reassess first: vitals trends, work of breathing, perfusion, mentation, and pain or ischemic equivalents when relevant. Boards reward recognizing when subtle instability outweighs reassurance, then selecting nursing actions that protect airway, circulation, and neurologic status before routine tasks.