Pathophysiology
Clinical meaning
Clinical reasoning integrates pattern recognition (System 1, fast/intuitive) with analytical reasoning (System 2, slow/deliberate). Bayesian reasoning adjusts disease probability based on sequential evidence: pre-test probability (based on prevalence, risk factors, presentation) is modified by test characteristics (sensitivity, specificity, likelihood ratios) to yield post-test probability. A test's utility depends on pre-test probability: high-sensitivity tests are best for ruling OUT disease (SnNout: Sensitive test, Negative result, rules Out); high-specificity tests are best for ruling IN disease (SpPin: Specific test, Positive result, rules In). The NP applies illness scripts (structured mental models of diseases with predisposing factors, pathophysiology, and clinical features), generates differential diagnoses, and systematically narrows them using history, exam, and testing.