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NCLEX-RN

Febrile Seizures

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Pathophysiology

A febrile seizure results when an immature brain encounters a rapid rise in temperature.

A febrile seizure results when an immature brain encounters a rapid rise in temperature. Myelination is incomplete, excitatory neurotransmission predominates, and the GABA‑mediated inhibitory reserve is low. Cytokines released during infection (IL‑1β, TNF‑α) amplify glutamate activity, pushing the seizure threshold even lower. The episode ends when the fever abates or the brain’s intrinsic inhibitory mechanisms recover.

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A febrile seizure results when an immature brain encounters a rapid rise in temperature.

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Febrile Seizures

Pathophysiology

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