Pathophysiology
Clinical meaning
Sepsis is life-threatening organ dysfunction from dysregulated host response to infection (Sepsis-3). qSOFA: AMS, SBP <=100, RR >=22. SOFA score >=2 from baseline. Septic shock: sepsis + vasopressors for MAP >=65 + lactate >2 despite adequate fluid. Hour-1 bundle: blood cultures, lactate, broad-spectrum antibiotics, 30 mL/kg crystalloid for hypotension or lactate >=4. Norepinephrine first-line vasopressor.