Maternal & Newborn
Pathophysiology
Obstetric hemorrhage involves unique physiological challenges: pregnancy increases blood volume by 40-50% (hypervolemic state), dilutional anemia masks true blood loss. Uterine blood flow at term is 500-700 mL/min, making atony catastrophic. Massive Transfusion Protocol (MTP) targets 1:1:1 ratio of pRBC:FFP:Platelets. Fibrinogen is the first coagulation factor depleted (critical threshold <200 mg/dL).
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