Pathophysiology
Clinical meaning
Atherosclerotic plaque rupture exposes the subendothelium to blood, activating the coagulation cascade. Platelets adhere via von Willebrand factor, activating GP IIb/IIIa receptors. Thrombus formation occludes the coronary artery, leading to anaerobic metabolism, ATP depletion, and cellular acidosis. Without reperfusion, necrosis begins in the subendocardium and extends transmurally. Connect STEMI: Molecular & Pharmacology to bedside cues you will reassess first: vitals trends, work of breathing, perfusion, mentation, and pain or ischemic equivalents when relevant. Boards reward recognizing when subtle instability outweighs reassurance, then selecting nursing actions that protect airway, circulation, and neurologic status before routine tasks.