Pathophysiology
Clinical overview
Harlequin Sign is a required newborn and neonatal concept because the first hours and days of life can shift quickly from normal transition to instability. The nurse links observation, thermoregulation, feeding, respiratory status, neurologic tone, skin findings, procedures, family teaching, and safety systems into one clinical picture. For CNPLE, this lesson keeps Harlequin Sign separate from adjacent newborn topics so learners can practice precise recognition instead of broad memorization.