Overview
Clinical Meaning
Kidney stones (nephrolithiasis) form when dissolved minerals in urine become supersaturated and crystallize.
Kidney stones (nephrolithiasis) form when dissolved minerals in urine become supersaturated and crystallize. The most common types are: Calcium oxalate (75-80%) — most common stone type overall, radiopaque on X-ray, associated with hypercalciuria, hyperoxaluria, and low urine volume. Calcium phosphate — often associated with renal tubular acidosis and hyperparathyroidism. Uric acid (5-10%) — the ONLY common stone type that is radiolucent (invisible on plain X-ray, visible on CT), forms in acidic urine (pH < 5.5), associated with gout and high-purine diets. Struvite/infection stones (5-15%) — composed of magnesium ammonium phosphate, form in alkaline urine infected with urease-producing bacteria (Proteus, Klebsiella), can form large 'staghorn' calculi filling the renal pelvis. Cystine stones (1-3%) — from inherited cystinuria, form hexagonal crystals in acidic urine. Stone prevention depends on type: increase fluid intake for all types (urine output > 2.5 L/day), dietary modifications, and type-specific interventions.
