Congenital hypothyroidism (CH) is one of the most common preventable causes of intellectual disability worldwide, occurring in approximately 1 in 2,000 to 4,000 live births. The condition results from insufficient production of thyroid hormones (thyroxine, T4, and triiodothyronine, T3) at or before birth. The thyroid gland develops from the foramen cecum at the base of the tongue during the third week of gestation and migrates to its final position in the anterior neck by the seventh week. Thyroid dysgenesis (abnormal gland development) accounts for approximately 85% of congenital hypothyroidism cases and includes thyroid agenesis (complete absence of the gland), thyroid ectopy (gland arrested at an abnormal location along the migration pathway, most commonly at the base of the tongue as a lingual thyroid), and thyroid hypoplasia (underdeveloped gland). The remaining 15% of cases result from dyshormonogenesis -- defects in any of the enzymatic steps of thyroid hormone synthesis, including iodide trapping, organification (iodination of tyrosine residues on thyroglobulin), coupling of iodotyrosines, or thyroglobulin synthesis and release. Thyroid hormones are essential for normal brain development, particularly during the first 2-3 years...