Pathophysiology
Clinical meaning
Valvular Disease involves specific alterations in valvular disease physiology. The pathophysiology of Valvular Disease encompasses changes in myocardial contractility, cardiac conduction, vascular resistance, endothelial function, or structural integrity depending on the primary mechanism involved. Key cellular processes include ion channel dysfunction, inflammatory mediator activation, oxidative stress, fibrotic remodeling, and neurohormonal dysregulation that drive the clinical manifestations of valvular disease.