Pathophysiology
Clinical meaning
Brugada Syndrome involves specific alterations in brugada syndrome physiology. The pathophysiology of Brugada Syndrome encompasses changes in myocardial contractility, cardiac conduction, vascular resistance, endothelial function, or structural integrity depending on the primary mechanism involved. Key cellular processes include ion channel dysfunction, inflammatory mediator activation, oxidative stress, fibrotic remodeling, and neurohormonal dysregulation that drive the clinical manifestations of brugada syndrome.