Pathophysiology
Clinical meaning
Tumor Lysis Syndrome: Uric Acid Crisis involves malignant transformation through accumulation of genetic mutations (oncogene activation, tumor suppressor loss) driving uncontrolled proliferation. The hallmarks of cancer include sustained proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, and activating invasion/metastasis. TNM staging guides prognosis and treatment decisions.