Systemic and Pulmonary Circulation involves specific alterations in systemic and pulmonary circulation physiology. The pathophysiology of Systemic and Pulmonary Circulation encompasses changes in myocardial contractility, cardiac conduction, vascular resistance, endothelial function, or structural integrity depending on the primary mechanism involved. Key cellular processes include ion channel dysfunction, inflammatory mediator activation, oxidative stress, fibrotic remodeling, and neurohormonal dysregulation that drive the clinical manifestations of systemic and pulmonary circulation.