Overview
Introduction and RN Clinical Focus
Pancreatic enzyme replacement therapy, commonly called PERT, is used when the pancreas does not release enough digestive enzymes into the small intestine.
Pancreatic enzyme replacement therapy, commonly called PERT, is used when the pancreas does not release enough digestive enzymes into the small intestine. This condition is called exocrine pancreatic insufficiency, or EPI. Without adequate enzymes, the client cannot properly digest and absorb nutrients, especially fat. NIDDK describes EPI as a condition where the small intestine cannot digest food normally, which can lead to malabsorption and malnutrition. (NIDDK) PERT is not a general stomach medication, antacid, antiemetic, or pain medication. It replaces digestive enzymes so the client can absorb nutrients from meals and snacks. NIDDK states that PERT is taken during meals or snacks to help the small intestine with digestion. (NIDDK) For the RN, the focus extends beyond safe administration. The RN must assess the full clinical picture: nutritional status, stool pattern, weight trends, abdominal symptoms, adherence barriers, medication technique, complications, and the need for interprofessional follow-up. The RN may also coordinate care with the prescriber, pharmacist, dietitian, gastroenterology team, cystic fibrosis team, oncology team, or home-care team depending on the underlying cause.